Ontology highlight
ABSTRACT:
SUBMITTER: Shinoda T
PROVIDER: S-EPMC5028891 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Shinoda Takehiro T Shinya Naoko N Ito Kaori K Ohsawa Noboru N Terada Takaho T Hirata Kunio K Kawano Yoshiaki Y Yamamoto Masaki M Kimura-Someya Tomomi T Yokoyama Shigeyuki S Shirouzu Mikako M
Scientific reports 20160920
The food-poisoning bacterium Clostridium perfringens produces an enterotoxin (~35 kDa) that specifically targets human claudin-4, among the 26 human claudin proteins, and causes diarrhea by fluid accumulation in the intestinal cavity. The C-terminal domain of the Clostridium perfringens enterotoxin (C-CPE, ~15 kDa) binds tightly to claudin-4, and disrupts the intestinal tight junction barriers. In this study, we determined the 3.5-Å resolution crystal structure of the cell-free synthesized human ...[more]