Ontology highlight
ABSTRACT:
SUBMITTER: Bermick JR
PROVIDER: S-EPMC5028999 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Bermick Jennifer R JR Lambrecht Nathalie J NJ denDekker Aaron D AD Kunkel Steven L SL Lukacs Nicholas W NW Hogaboam Cory M CM Schaller Matthew A MA
Clinical epigenetics 20160920
<h4>Background</h4>Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptible to infections, but the factors regulating neonatal-specific immune responses are poorly understood. Epigenetics, including histone modifications, can activate or silence gene transcription by modulating chromatin structure and stability without affecting the DNA sequence itself and are potentially modifiable. Histone modifications are known to ...[more]