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Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.

ABSTRACT: BACKGROUND:Rheumatoid arthritis (RA) has been associated with lower socioeconomic status (SES), but the reasons for this are not known. OBJECTIVE:To examine childhood SES measures, SES trajectory and other perinatal factors in relation to RA. METHODS:The sample included 50 884 women, aged 35-74 (84% non-Hispanic white) enrolled 2004-9 in a US national cohort study. In baseline questionnaires, cases (N=424, 0.8%) reported RA diagnosis after age 16, ever use of disease-modifying antirheumatic drugs or steroids for RA and ?6 weeks bilateral joint swelling. Childhood SES measures are presented as OR and 95% CI adjusted for age and race/ethnicity. Analyses of perinatal factors also adjusted for childhood SES, and joint effects of childhood and adult SES and smoking exposures were evaluated. RESULTS:Patients with RA reported lower childhood household education (<12 years vs college degree; OR=1.7; 95% CI 1.1 to 2.5), food insecurity (OR=1.5, 95% CI 1.1 to 2.0) and young maternal age (<20 vs 20-34 years; OR=1.7, 95% CI 1.2 to 2.5), with a trend (p<0.0001) for increasing number of adverse factors (OR=3.0; 95% CI 1.3 to 7.0; 4 vs 0 factors) compared with non-cases. Low birth weight (<2500 g) [corrected] and preconception paternal smoking were independently associated with RA. Together, lower childhood SES and adult education (

SUBMITTER: Parks CG

PROVIDER: S-EPMC5029277 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.

Parks Christine G CG D'Aloisio Aimee A AA DeRoo Lisa A LA Huiber Kirstin K Rider Lisa G LG Miller Frederick W FW Sandler Dale P DP

Annals of the rheumatic diseases 20120514 3

<h4>Background</h4>Rheumatoid arthritis (RA) has been associated with lower socioeconomic status (SES), but the reasons for this are not known.<h4>Objective</h4>To examine childhood SES measures, SES trajectory and other perinatal factors in relation to RA.<h4>Methods</h4>The sample included 50 884 women, aged 35-74 (84% non-Hispanic white) enrolled 2004-9 in a US national cohort study. In baseline questionnaires, cases (N=424, 0.8%) reported RA diagnosis after age 16, ever use of disease-modify ...[more]

PMID: 22586176

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Project description:BackgroundCardiovascular health shows significant socioeconomic inequalities, however there is little understanding of the role of early adulthood in generation of these inequalities. We assessed the contribution of socioeconomic trajectories during early adulthood (16-24 years) to cardiovascular health in mid-adulthood (46 years).MethodsParticipants from the 1970 British Cohort Study with socioeconomic data available in early adulthood were included (n=12 423). Longitudinal latent class analysis identified socioeconomic trajectories, based on patterns of economic activity throughout early adulthood. Cardiometabolic risk factors (46 years) were regressed on socioeconomic trajectory class (16-24 years), testing mediation by adult socioeconomic position (46 years). Models were stratified by sex and adjusted for childhood socioeconomic position (SEP) and adolescent health.ResultsSix early adulthood socioeconomic trajectories were identified: (1) Continued Education (20.2%), (2) Managerial Employment (16.0%), (3) Skilled Non-manual Employment (20.9%), (4) Skilled Manual Employment (18.9%), (5) Partly Skilled Employment (15.8%) and (6) Economically Inactive (8.1%). The 'Continued Education' trajectory class showed the best cardiovascular health at age 46 years, with the lowest levels of cardiometabolic risk factors. For example, systolic blood pressure was 128.9 mm Hg (95% CI 127.8 to 130.0) among men in the 'Continued Education' class, compared with 131.3 mm Hg (95% CI 130.4 to 132.2) among men in the 'Skilled Manual' class. Patterns across classes 2-6 differed by risk factor and sex. The observed associations were largely not mediated by SEP at age 46 years.ConclusionFindings suggest an independent contribution of early adulthood socioeconomic trajectories to development of later life cardiovascular inequalities. Further work is needed to understand mediators of this relationship and potential for interventions to mitigate these pathways.

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Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.

Publications

Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.

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