Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal.
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ABSTRACT:
SUBMITTER: Kim SO
PROVIDER: S-EPMC5029471 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Mapping PTGERs to the Ovulatory Follicle: Regional Responses to the Ovulatory PGE2 Signal.
Kim Soon Ok SO Duffy Diane M DM
Biology of reproduction 20160615 2
Prostaglandin E2 (PGE2) is a key intrafollicular mediator of ovulation in many, if not all, mammalian species. PGE2 acts at follicular cells via four distinct PGE2 receptors (PTGERs). Within the ovulatory follicle, each cell type (e.g., oocyte, cumulus granulosa cell, mural granulosa cell, theca cell, endothelial cell) expresses a different subset of the four PTGERs. Expression of a subset of PTGERs has consequences for the generation of intracellular signals and ultimately the unique functions ...[more]
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