Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC5029650 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lu Yuan Y Wang Yuan Y Zhang Mi M Liu Li L Li Fakai F Zhang Jian J Ye Mingxiang M Zhao Hu H Zhao Jing J Yan Bo B Yang Angang A Zhang Rui R Li Xia X Ren Xinling X
Oncotarget 20160401 17
Overexpression of human epidermal growth factor receptor type2 (HER2) is closely associated with aggressive progression and poor prognosis in non-small cell lung cancer (NSCLC). Here, we generated an EGFR-scFv-arginine nonamer peptide fusion protein (scFv-9R) as a cargo to deliver HER2 specific siRNA into HER2-positive NSCLC cells both in vitro and in vivo. HER2-siRNAs delivered by scFv-9R effeciently silenced HER2 expression in EGFR-positive NSCLC cells, and consequently resulted in G1 arrest a ...[more]