Ontology highlight
ABSTRACT:
SUBMITTER: Labrecque MP
PROVIDER: S-EPMC5029701 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Labrecque Mark P MP Takhar Mandeep K MK Nason Rebecca R Santacruz Stephanie S Tam Kevin J KJ Massah Shabnam S Haegert Anne A Bell Robert H RH Altamirano-Dimas Manuel M Collins Colin C CC Lee Frank J S FJ Prefontaine Gratien G GG Cox Michael E ME Beischlag Timothy V TV
Oncotarget 20160401 17
Loss of tumor suppressor proteins, such as the retinoblastoma protein (Rb), results in tumor progression and metastasis. Metastasis is facilitated by low oxygen availability within the tumor that is detected by hypoxia inducible factors (HIFs). The HIF1 complex, HIF1α and dimerization partner the aryl hydrocarbon receptor nuclear translocator (ARNT), is the master regulator of the hypoxic response. Previously, we demonstrated that Rb represses the transcriptional response to hypoxia by virtue of ...[more]