Dataset Information

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma.

ABSTRACT:

Background

We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma.

Patients and methods

A total of 125 liposarcoma tissue samples were collected over a 12-year period. PIK3CA mutations and gene copy number amplifications were analyzed by pyrosequencing and fluorescence in situ hybridization (FISH).

Results

Nine of the 105 liposarcomas (8.6%) had activating PIK3CA mutation. PIK3CA mutations were more frequent in myxoid/round cell and pleomorphic tumors compared with well-differentiated/dedifferentiated tumors (13.3% vs. 2.2%, P=0.043). In FISH PIK3CA analysis, copy number gain was detected in 14 of the 101 tumors (13.9%): 11 (10.9%) tumors had increased gene copy number (polysomy) and 3 (3.0%) exhibited gene amplification. In survival analysis, patients with PIK3CA copy number gain had a worse prognosis compared to patients without PIK3CA amplification (median disease-free survival [DFS] 22.2 vs. 107.6 months p=0.005). By multivariate analysis, PIK3CA copy number gain was an independent prognostic factor for worse DFS (P=0.027; hazard ratio, 2.400; 95% confidence interval 1.105 to 5.213). PIK3CA mutation was not associated with DFS and overall survival.

Conclusions

We demonstrated PIK3CA mutation and amplification in liposarcoma. PIK3CA copy number gain was an independent poor prognostic factor for DFS. Further studies are needed to evaluate the potential diagnostic and therapeutic role of PIK3CA mutations and amplifications in liposarcoma.

SUBMITTER: Kim JH

PROVIDER: S-EPMC5029721 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Publications

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma.

Kim Joo Hoon JH Lee Jae Seok JS Kim Eo Jin EJ Park Kyu Hyun KH Kim Ki Hyang KH Yi Seong Yoon SY Kim Han Seong HS Cho Yong Jin YJ Shin Kyoo-Ho KH Ahn Joong Bae JB Hu Hyuk H Kim Kyung Sik KS Choi Young Deuk YD Kim Sunghoon S Lee Young Han YH Suh Jin-Suck JS Noh Sung Hoon SH Rha Sun Young SY Kim Hyo Song HS

Oncotarget 20160401 17

<h4>Background</h4>We investigated the epidemiologic characteristics and prognostic significance of PIK3CA mutations/amplifications in curative resected liposarcoma.<h4>Patients and methods</h4>A total of 125 liposarcoma tissue samples were collected over a 12-year period. PIK3CA mutations and gene copy number amplifications were analyzed by pyrosequencing and fluorescence in situ hybridization (FISH).<h4>Results</h4>Nine of the 105 liposarcomas (8.6%) had activating PIK3CA mutation. PIK3CA muta ...[more]

PMID: 27016421

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Dataset Information

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma.

Background

Patients and methods

Results

Conclusions

Publications

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma.

Similar Datasets

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