A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly.
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ABSTRACT:
SUBMITTER: Healy EF
PROVIDER: S-EPMC5030186 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
A mechanism for propagated SOD1 misfolding from frustration analysis of a G85R mutant protein assembly.
Biochemical and biophysical research communications 20160831 4
Application of landscape theory and the dehydron hypothesis to a crystal structure of a G85R mutant superoxide dismutase (SOD1) tetrameric complex allows for the description of a prion-like hypothesis that serves to explain propagated SOD1 misfolding. We have developed two conformational-change scenarios, one local to the ESL at the complex interface, and a second displacement at the ESL of the otherdimeric subunit. When taken together these provide for a prion-like mechanism that can serve to e ...[more]
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