Unknown

Dataset Information

0

Cognitive Slowing in Gulf War Illness Predicts Executive Network Hyperconnectivity: Study in a Population-Representative Sample.


ABSTRACT: Cognitive slowing is a prevalent symptom observed in Gulf War Illness (GWI). The present study assessed the extent to which functional connectivity between dorsolateral prefrontal cortex (DLPFC) and other task-relevant brain regions was predictive of GWI-related cognitive slowing. GWI patients (n = 54) and healthy veteran controls (n = 29) were assessed on performance of a processing speed task (the Digit Symbol Substitution Task; DSST) while undergoing functional magnetic resonance imaging (fMRI). GWI patients were slower on the DSST relative to controls. Bilateral DLPFC connectivity with task-relevant nodes was altered in GWI patients compared to healthy controls during DSST performance. Moreover, hyperconnectivity in these networks predicted GWI-related increases in reaction time on the DSST, whereas hypoconnectivity did not. These results suggest that GWI-related cognitive slowing reflects reduced efficiency in cortical networks.

SUBMITTER: Turner MP 

PROVIDER: S-EPMC5030369 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cognitive Slowing in Gulf War Illness Predicts Executive Network Hyperconnectivity: Study in a Population-Representative Sample.

Turner Monroe P MP   Hubbard Nicholas A NA   Himes Lyndahl M LM   Faghihahmadabadi Shawheen S   Hutchison Joanna L JL   Bennett Ilana J IJ   Motes Michael A MA   Haley Robert W RW   Rypma Bart B  

NeuroImage. Clinical 20160826


Cognitive slowing is a prevalent symptom observed in Gulf War Illness (GWI). The present study assessed the extent to which functional connectivity between dorsolateral prefrontal cortex (DLPFC) and other task-relevant brain regions was predictive of GWI-related cognitive slowing. GWI patients (n = 54) and healthy veteran controls (n = 29) were assessed on performance of a processing speed task (the Digit Symbol Substitution Task; DSST) while undergoing functional magnetic resonance imaging (fMR  ...[more]

Similar Datasets

| S-EPMC3612516 | biostudies-literature
| S-EPMC4352953 | biostudies-literature
2017-02-01 | PXD005185 | Pride
2019-03-15 | GSE112905 | GEO
| PRJEB19474 | ENA
| S-EPMC6660083 | biostudies-literature
| S-EPMC6899710 | biostudies-literature
| S-EPMC7579364 | biostudies-literature
2023-06-01 | GSE225179 | GEO
| S-EPMC8615505 | biostudies-literature