Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels.
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ABSTRACT:
SUBMITTER: Kuzmenkov AI
PROVIDER: S-EPMC5030662 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels.
Kuzmenkov Alexey I AI Nekrasova Oksana V OV Kudryashova Kseniya S KS Peigneur Steve S Tytgat Jan J Stepanov Alexey V AV Kirpichnikov Mikhail P MP Grishin Eugene V EV Feofanov Alexey V AV Vassilevski Alexander A AA
Scientific reports 20160921
Ion channels play a central role in a host of physiological and pathological processes and are the second largest target for existing drugs. There is an increasing need for reliable tools to detect and visualize particular ion channels, but existing solutions suffer from a number of limitations such as high price, poor specificity, and complicated protocols. As an alternative, we produced recombinant chimeric constructs (FP-Tx) consisting of fluorescent proteins (FP) fused with potassium channel ...[more]
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