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Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity.


ABSTRACT: Objective?Our primary objective was to assess the difference in amino and fatty acid biomarkers throughout pregnancy in women with and without obesity. Interactions between biomarkers and obesity status for associations with maternal and fetal metabolic measures were secondarily analyzed. Methods?Overall 39 women (15 cases, 24 controls) were enrolled in this study during their 15- to 20-weeks' visit at the University of Iowa Hospitals and Clinics. We analyzed 32 amino acid and acylcarnitine concentrations with tandem mass spectrometry for differences throughout pregnancy as well as among women with and without obesity (body mass index [BMI] ? 35, BMI?

SUBMITTER: Ryckman KK 

PROVIDER: S-EPMC5031496 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity.

Ryckman Kelli K KK   Donovan Brittney M BM   Fleener Diedre K DK   Bedell Bruce B   Borowski Kristi S KS  

AJP reports 20160701 3


Objective Our primary objective was to assess the difference in amino and fatty acid biomarkers throughout pregnancy in women with and without obesity. Interactions between biomarkers and obesity status for associations with maternal and fetal metabolic measures were secondarily analyzed. Methods Overall 39 women (15 cases, 24 controls) were enrolled in this study during their 15- to 20-weeks' visit at the University of Iowa Hospitals and Clinics. We analyzed 32 amino acid and acylcarnitine conc  ...[more]

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