Ontology highlight
ABSTRACT:
SUBMITTER: Sadeh R
PROVIDER: S-EPMC5031555 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Sadeh Ronen R Launer-Wachs Roee R Wandel Hava H Rahat Ayelet A Friedman Nir N
Molecular cell 20160802 6
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has been instrumental to our current view of chromatin structure and function. It allows genome-wide mapping of histone marks, which demarcate biologically relevant domains. However, ChIP-seq is an ensemble measurement reporting the average occupancy of individual marks in a cell population. Consequently, our understanding of the combinatorial nature of chromatin states relies almost exclusively on correlation between the genomic di ...[more]