Curli mediate bacterial adhesion to fibronectin via tensile multiple bonds.
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ABSTRACT:
SUBMITTER: Oh YJ
PROVIDER: S-EPMC5031991 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Curli mediate bacterial adhesion to fibronectin via tensile multiple bonds.
Oh Yoo Jin YJ Hubauer-Brenner Michael M Gruber Hermann J HJ Cui Yidan Y Traxler Lukas L Siligan Christine C Park Sungsu S Hinterdorfer Peter P
Scientific reports 20160922
Many enteric bacteria including pathogenic Escherichia coli and Salmonella strains produce curli fibers that bind to host surfaces, leading to bacterial internalization into host cells. By using a nanomechanical force-sensing approach, we obtained real-time information about the distribution of molecular bonds involved in the adhesion of curliated bacteria to fibronectin. We found that curliated E. coli and fibronectin formed dense quantized and multiple specific bonds with high tensile strength ...[more]
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