Dataset Information

Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe.

ABSTRACT: Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (B_PANDEMIC) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (B_CAR) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estimate the prevalence and to reconstruct the spatiotemporal dynamics of dissemination of HIV-1 B_CAR strains in those regions. We find that B_CAR strains were probably disseminated from the Caribbean into North America and Europe at multiple times since the early 1970s onwards. The B_CAR strains reached the US, Canada and at least 16 different European countries, where they account for a very low fraction (<5%) of subtype B infections, with exception of the Czech Republic (7.7%). We also find evidence of the onward transmission of B_CAR clades in the US, Canada, the Czech Republic, Germany, Italy, Spain and the UK, as well as short-distance spreading of B_CAR lineages between neighboring European countries from Central and Western Europe, and long-distance dissemination between the US and Europe.

SUBMITTER: Cabello M

PROVIDER: S-EPMC5032033 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe.

Cabello Marina M Romero Hector H Bello Gonzalo G

Scientific reports 20160922

Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (B<sub>PANDEMIC</sub>) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (B<sub>CAR</sub>) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estim ...[more]

PMID: 27653834

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Dataset Information

Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe.

Publications

Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe.

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