Ontology highlight
ABSTRACT:
SUBMITTER: Guan Y
PROVIDER: S-EPMC5033581 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Guan Yihong Y Huang Delai D Chen Feng F Gao Ce C Tao Ting T Shi Hui H Zhao Shuyi S Liao Zuyuan Z Lo Li Jan LJ Wang Yingchun Y Chen Jun J Peng Jinrong J
PLoS biology 20160922 9
Digestive organ expansion factor (Def) is a nucleolar protein that plays dual functions: it serves as a component of the ribosomal small subunit processome for the biogenesis of ribosomes and also mediates p53 degradation through the cysteine proteinase calpain-3 (CAPN3). However, nothing is known about the exact relationship between Def and CAPN3 or the regulation of the Def function. In this report, we show that CAPN3 degrades p53 and its mutant proteins p53A138V, p53M237I, p53R248W, and p53R2 ...[more]