Ontology highlight
ABSTRACT:
SUBMITTER: Bae HR
PROVIDER: S-EPMC5033675 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Bae Heekyong R HR Leung Patrick S C PS Tsuneyama Koichi K Valencia Julio C JC Hodge Deborah L DL Kim Seohyun S Back Tim T Karwan Megan M Merchant Anand S AS Baba Nobuyuki N Feng Dechun D Park Ogyi O Gao Bin B Yang Guo-Xiang GX Gershwin M Eric ME Young Howard A HA
Hepatology (Baltimore, Md.) 20160615 4
<h4>Unlabelled</h4>In most autoimmune diseases the serologic hallmarks of disease precede clinical pathology by years. Therefore, the use of animal models in defining early disease events becomes critical. We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNγ) characterized by prolonged and chronic expression of IFNγ through deletion of the IFNγ 3'-untranslated region adenylate uridylate-rich element (ARE). The ARE-Del(-/-) mice develop primary biliary cholangitis ...[more]