Ontology highlight
ABSTRACT:
SUBMITTER: Sittig LJ
PROVIDER: S-EPMC5033712 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Sittig Laura J LJ Carbonetto Peter P Engel Kyle A KA Krauss Kathleen S KS Barrios-Camacho Camila M CM Palmer Abraham A AA
Neuron 20160908 6
Genome-wide association studies (GWASs) have identified numerous loci that influence risk for psychiatric diseases. Genetically engineered mice are often used to characterize genes implicated by GWASs. These studies are based on the assumption that observed genotype-phenotype relationships will generalize to humans, implying that the results would at least generalize to other inbred mouse strains. Given current concerns about reproducibility, we sought to directly test this assumption. We produc ...[more]