Ontology highlight
ABSTRACT:
SUBMITTER: Tian J
PROVIDER: S-EPMC5033723 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Tian Ju J Huang Ryan R Cohen Jeremiah Y JY Osakada Fumitaka F Kobak Dmitry D Machens Christian K CK Callaway Edward M EM Uchida Naoshige N Watabe-Uchida Mitsuko M
Neuron 20160908 6
Dopamine neurons encode the difference between actual and predicted reward, or reward prediction error (RPE). Although many models have been proposed to account for this computation, it has been difficult to test these models experimentally. Here we established an awake electrophysiological recording system, combined with rabies virus and optogenetic cell-type identification, to characterize the firing patterns of monosynaptic inputs to dopamine neurons while mice performed classical conditionin ...[more]