Ontology highlight
ABSTRACT:
SUBMITTER: Nakatake S
PROVIDER: S-EPMC5033752 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nakatake Shunji S Murakami Yusuke Y Ikeda Yasuhiro Y Morioka Noriko N Tachibana Takashi T Fujiwara Kohta K Yoshida Noriko N Notomi Shoji S Hisatomi Toshio T Yoshida Shigeo S Ishibashi Tatsuro T Nakabeppu Yusaku Y Sonoda Koh-Hei KH
JCI insight 20160922 15
Oxidative stress is implicated in various neurodegenerative disorders, including retinitis pigmentosa (RP), an inherited disease that causes blindness. The biological and cellular mechanisms by which oxidative stress mediates neuronal cell death are largely unknown. In a mouse model of RP (rd10 mice), we show that oxidative DNA damage activates microglia through MutY homolog-mediated (MUYTH-mediated) base excision repair (BER), thereby exacerbating retinal inflammation and degeneration. In the e ...[more]