Ontology highlight
ABSTRACT:
SUBMITTER: Ahadome SD
PROVIDER: S-EPMC5033866 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Ahadome Sarah D SD Abraham David J DJ Rayapureddi Suryanarayana S Saw Valerie P VP Saban Daniel R DR Calder Virginia L VL Norman Jill T JT Ponticos Markella M Daniels Julie T JT Dart John K JK
JCI insight 20160804 12
Mucous membrane pemphigoid (MMP) is a systemic mucosal scarring disease, commonly causing blindness, for which there is no antifibrotic therapy. Aldehyde dehydrogenase family 1 (ALDH1) is upregulated in both ocular MMP (OMMP) conjunctiva and cultured fibroblasts. Application of the ALDH metabolite, retinoic acid (RA), to normal human conjunctival fibroblasts in vitro induced a diseased phenotype. Conversely, application of ALDH inhibitors, including disulfiram, to OMMP fibroblasts in vitro resto ...[more]