Ontology highlight
ABSTRACT:
SUBMITTER: Djureinovic D
PROVIDER: S-EPMC5033889 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Djureinovic Dijana D Hallström Björn M BM Horie Masafumi M Mattsson Johanna Sofia Margareta JSM La Fleur Linnea L Fagerberg Linn L Brunnström Hans H Lindskog Cecilia C Madjar Katrin K Rahnenführer Jörg J Ekman Simon S Ståhle Elisabeth E Koyi Hirsh H Brandén Eva E Edlund Karolina K Hengstler Jan G JG Lambe Mats M Saito Akira A Botling Johan J Pontén Fredrik F Uhlén Mathias M Micke Patrick P
JCI insight 20160707 10
Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small-cell lung cancer (NSCLC), we compared RNAseq data from 199 NSCLC tissues to the normal transcriptome of 142 samples from 32 different normal organs. Of 232 CTAs currently annotated in the Caner Testis Database (CTdatabase), 96 were confirmed in NSCLC. To obtain an unbiased CTA profile of NSCLC, we applied stringent cri ...[more]