Ontology highlight
ABSTRACT:
SUBMITTER: Federico G
PROVIDER: S-EPMC5033928 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Federico Giuseppina G Meister Michael M Mathow Daniel D Heine Gunnar H GH Moldenhauer Gerhard G Popovic Zoran V ZV Nordström Viola V Kopp-Schneider Annette A Hielscher Thomas T Nelson Peter J PJ Schaefer Franz F Porubsky Stefan S Fliser Danilo D Arnold Bernd B Gröne Hermann-Josef HJ
JCI insight 20160121 1
Renal tubular atrophy and interstitial fibrosis are common hallmarks of etiologically different progressive chronic kidney diseases (CKD) that eventually result in organ failure. Even though these pathological manifestations constitute a major public health problem, diagnostic tests, as well as therapeutic options, are currently limited. Members of the dickkopf (DKK) family, DKK1 and -2, have been associated with inhibition of Wnt signaling and organ fibrosis. Here, we identify DKK3 as a stress- ...[more]