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Management of malignant pleural mesothelioma-part 2: therapeutic approaches : Consensus of the Austrian Mesothelioma Interest Group (AMIG).


ABSTRACT: Treatment of malignant pleural mesothelioma (MPM) depends on performance status of the patient, tumor stage, and histological differentiation. Chemotherapy (CHT) can be administered as first- and second-line treatment in unresectable MPM or as neoadjuvant or adjuvant treatment before or after surgery. A combination of an antifolate and platinum-based CHT is the only approved standard of care. Several targeted and immunotherapies are in evaluation and further studies are warranted to determine the therapeutic value of these new treatment options. Radiotherapy (RT) can be considered either as adjuvant treatment after surgery or for palliation of pain-related tumor growth. Recent data support the use of RT in a neoadjuvant setting. Macroscopic complete resection by pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP) is indicated in selected patients with good performance status. Surgery should only be applied as part of a multimodality treatment (MMT) in combination with chemo- and/or radiotherapy. In a large number of cases, palliative attempts are needed to improve quality of life and to achieve symptom control.

SUBMITTER: Hoda MA 

PROVIDER: S-EPMC5033993 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Management of malignant pleural mesothelioma-part 2: therapeutic approaches : Consensus of the Austrian Mesothelioma Interest Group (AMIG).

Hoda Mir Alireza MA   Klikovits Thomas T   Arns Madeleine M   Dieckmann Karin K   Zöchbauer-Müller Sabine S   Geltner Christian C   Baumgartner Bernhard B   Errhalt Peter P   Machan Barbara B   Pohl Wolfgang W   Hutter Jörg J   Eckmayr Josef J   Studnicka Michael M   Flicker Martin M   Cerkl Peter P   Klepetko Walter W  

Wiener klinische Wochenschrift 20160725 17-18


Treatment of malignant pleural mesothelioma (MPM) depends on performance status of the patient, tumor stage, and histological differentiation. Chemotherapy (CHT) can be administered as first- and second-line treatment in unresectable MPM or as neoadjuvant or adjuvant treatment before or after surgery. A combination of an antifolate and platinum-based CHT is the only approved standard of care. Several targeted and immunotherapies are in evaluation and further studies are warranted to determine th  ...[more]

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