Ontology highlight
ABSTRACT:
SUBMITTER: Xiong J
PROVIDER: S-EPMC5034322 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Xiong Jing J Zhou Ming-Feng MF Wang Ya-Dong YD Chen Li-Ping LP Xu Wan-Fu WF Wang Yao-Dong YD Deng Fan F Liu Si-de SD
Scientific reports 20160923
Inflammatory bowel disease is characterized by dysregulation of the mucosal immune system resulting from impaired intestinal epithelial barrier function. Protein kinase D2 has been implicated in the regulation of immune responses. The present study was to define PKD2 might affect murine colitis. Colitis was induced in wild-type mice (PKD2<sup>WT/WT</sup>) and PKD2 catalytic activity deficient mice (PKD2<sup>SSAA/SSAA</sup>) with dextran sulfate sodium. PKD2<sup>SSAA</sup>-knockin mice displayed ...[more]