Ontology highlight
ABSTRACT:
SUBMITTER: Jorgensen C
PROVIDER: S-EPMC5034363 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Jorgensen Christian C Furini Simone S Domene Carmen C
Biophysical journal 20160901 6
Ion channels enable diffusion of ions down physiological electrochemical gradients. Modulation of ion permeation is crucial for the physiological functioning of cells, and misregulation of ion channels is linked to a myriad of channelopathies. The ion permeation mechanism in the transient receptor potential (TRP) ion channel family is currently not understood at an atomistic level. In this work, we employed a simulation strategy for ion permeation (molecular-dynamics simulations with bias-exchan ...[more]