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The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species.


ABSTRACT: The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control.The 479 Mb medfly genome is sequenced from adult flies from lines inbred for 20 generations. A high-quality assembly is achieved having a contig N50 of 45.7 kb and scaffold N50 of 4.06 Mb. In-depth curation of more than 1800 messenger RNAs shows specific gene expansions that can be related to invasiveness and host adaptation, including gene families for chemoreception, toxin and insecticide metabolism, cuticle proteins, opsins, and aquaporins. We identify genes relevant to IPM control, including those required to improve SIT.The medfly genome sequence provides critical insights into the biology of one of the most serious and widespread agricultural pests. This knowledge should significantly advance the means of controlling the size and invasive potential of medfly populations. Its close relationship to Drosophila, and other insect species important to agriculture and human health, will further comparative functional and structural studies of insect genomes that should broaden our understanding of gene family evolution.

SUBMITTER: Papanicolaou A 

PROVIDER: S-EPMC5034548 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species.

Papanicolaou Alexie A   Schetelig Marc F MF   Arensburger Peter P   Atkinson Peter W PW   Benoit Joshua B JB   Bourtzis Kostas K   Castañera Pedro P   Cavanaugh John P JP   Chao Hsu H   Childers Christopher C   Curril Ingrid I   Dinh Huyen H   Doddapaneni HarshaVardhan H   Dolan Amanda A   Dugan Shannon S   Friedrich Markus M   Gasperi Giuliano G   Geib Scott S   Georgakilas Georgios G   Gibbs Richard A RA   Giers Sarah D SD   Gomulski Ludvik M LM   González-Guzmán Miguel M   Guillem-Amat Ana A   Han Yi Y   Hatzigeorgiou Artemis G AG   Hernández-Crespo Pedro P   Hughes Daniel S T DS   Jones Jeffery W JW   Karagkouni Dimitra D   Koskinioti Panagiota P   Lee Sandra L SL   Malacrida Anna R AR   Manni Mosè M   Mathiopoulos Kostas K   Meccariello Angela A   Munoz-Torres Monica   Murali Shwetha C SC   Murphy Terence D TD   Muzny Donna M DM   Oberhofer Georg G   Ortego Félix F   Paraskevopoulou Maria D MD   Poelchau Monica M   Qu Jiaxin J   Reczko Martin M   Robertson Hugh M HM   Rosendale Andrew J AJ   Rosselot Andrew E AE   Saccone Giuseppe G   Saccone Giuseppe G   Salvemini Marco M   Savini Grazia G   Schreiner Patrick P   Schreiner Patrick P   Scolari Francesca F   Siciliano Paolo P   Sim Sheina B SB   Tsiamis George G   Ureña Enric E   Vlachos Ioannis S IS   Werren John H JH   Wimmer Ernst A EA   Worley Kim C KC   Zacharopoulou Antigone A   Richards Stephen S   Handler Alfred M AM  

Genome biology 20160922 1


<h4>Background</h4>The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and m  ...[more]

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