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DNA methylation and smoking in Korean adults: epigenome-wide association study.


ABSTRACT: Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely understood. Epigenome-wide association studies (EWASs), mostly in non-Asian populations, have been conducted to identify smoking-associated methylation alterations at individual probes. There are few data on regional methylation changes in relation to smoking. Few data link differential methylation in blood to differential gene expression in lung tissue.We identified 108 significant (false discovery rate (FDR)

SUBMITTER: Lee MK 

PROVIDER: S-EPMC5034618 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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DNA methylation and smoking in Korean adults: epigenome-wide association study.

Lee Mi Kyeong MK   Hong Yoonki Y   Kim Sun-Young SY   London Stephanie J SJ   Kim Woo Jin WJ  

Clinical epigenetics 20160922


<h4>Background</h4>Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely understood. Epigenome-wide association studies (EWASs), mostly in non-Asian populations, have been conducted to identify smoking-associated methylation alterations at individual probes. There are few data on regional methylation changes in relation to smoking. Few data link di  ...[more]

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