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Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in Japanese subjects with impaired glucose tolerance.

ABSTRACT: To evaluate the efficacy and tolerability of sitagliptin in subjects with impaired glucose tolerance (IGT).In a double-blind, parallel-group study, 242 Japanese subjects with IGT, determined by a 75-g oral glucose tolerance test (OGTT) at week -1, were randomized (1?:?1?:?1) to placebo (n?=?83), sitagliptin 25?mg (n?=?82) or 50?mg (n?=?77) once daily for 8?weeks. Glycaemic variables were assessed using another OGTT at week 7 and meal tolerance tests (MTTs) at weeks 0 and 8. Primary and secondary endpoints were percent change from baseline in glucose total area under the curve 0-2?h (AUC(0 -2?h)) during the MTT and OGTT, respectively.Least squares mean percent change from baseline in glucose AUC(0 -2?h) during the MTT were -2.4, -9.5 and -11.5%, and during the OGTT were -3.7, -21.4 and -20.1% with placebo, sitagliptin 25?mg once daily, and 50?mg once daily, respectively (p?

SUBMITTER: Kaku K 

PROVIDER: S-EPMC5034821 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Sitagliptin improves glycaemic excursion after a meal or after an oral glucose load in Japanese subjects with impaired glucose tolerance.

Kaku K K   Kadowaki T T   Terauchi Y Y   Okamoto T T   Sato A A   Okuyama K K   Arjona Ferreira J C JC   Goldstein B J BJ  

Diabetes, obesity & metabolism 20150717 11

<h4>Aims</h4>To evaluate the efficacy and tolerability of sitagliptin in subjects with impaired glucose tolerance (IGT).<h4>Methods</h4>In a double-blind, parallel-group study, 242 Japanese subjects with IGT, determined by a 75-g oral glucose tolerance test (OGTT) at week -1, were randomized (1 : 1 : 1) to placebo (n = 83), sitagliptin 25 mg (n = 82) or 50 mg (n = 77) once daily for 8 weeks. Glycaemic variables were assessed using another OGTT at week 7 and meal tolerance tests (MTTs) at weeks 0  ...[more]

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