Ontology highlight
ABSTRACT:
SUBMITTER: Bogorad MI
PROVIDER: S-EPMC5035133 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bogorad Max I MI Searson Peter C PC
Integrative biology : quantitative biosciences from nano to macro 20160815 9
Here we report on real-time imaging and quantitative analysis of solute transport in perfusable cylindrical microvessels formed from Madin-Darby canine kidney (MDCK) cells embedded in a collagen matrix. Fluorescence microscopy was used to image the kinetics of doxorubicin transport following injection. To assess the role of efflux pumps on transport, experiments were performed in microvessels formed from MDCK.2, MDCKII-w/t, and MDCKII-MDR1 cells. MDCKII-w/t and MDCKII-MDR1 showed significant dox ...[more]