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Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

ABSTRACT: Taenia saginata, Taenia solium and Taenia asiatica (beef, pork and Asian tapeworms, respectively) are parasitic flatworms of major public health and food safety importance. Among them, T. asiatica is a newly recognized species that split from T. saginata via an intermediate host switch ?1.14 Myr ago. Here we report the 169- and 168-Mb draft genomes of T. saginata and T. asiatica. Comparative analysis reveals that high rates of gene duplications and functional diversifications might have partially driven the divergence between T. asiatica and T. saginata. We observe accelerated evolutionary rates, adaptive evolutions in homeostasis regulation, tegument maintenance and lipid uptakes, and differential/specialized gene family expansions in T. asiatica that may favour its hepatotropism in the new intermediate host. We also identify potential targets for developing diagnostic or intervention tools against human tapeworms. These data provide new insights into the evolution of Taenia parasites, particularly the recent speciation of T. asiatica.

SUBMITTER: Wang S

PROVIDER: S-EPMC5036155 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

Wang Shuai S Wang Sen S Luo Yingfeng Y Xiao Lihua L Luo Xuenong X Gao Shenghan S Dou Yongxi Y Zhang Huangkai H Guo Aijiang A Meng Qingshu Q Hou Junling J Zhang Bing B Zhang Shaohua S Yang Meng M Meng Xuelian X Mei Hailiang H Li Hui H He Zilong Z Zhu Xueliang X Tan Xinyu X Zhu Xing-Quan XQ Yu Jun J Cai Jianping J Zhu Guan G Hu Songnian S Cai Xuepeng X

Nature communications 20160922

Taenia saginata, Taenia solium and Taenia asiatica (beef, pork and Asian tapeworms, respectively) are parasitic flatworms of major public health and food safety importance. Among them, T. asiatica is a newly recognized species that split from T. saginata via an intermediate host switch ∼1.14 Myr ago. Here we report the 169- and 168-Mb draft genomes of T. saginata and T. asiatica. Comparative analysis reveals that high rates of gene duplications and functional diversifications might have partiall ...[more]

PMID: 27653464

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Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

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Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

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