Ontology highlight
ABSTRACT:
SUBMITTER: Ow JR
PROVIDER: S-EPMC5036183 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Ow Jin Rong JR Palanichamy Kala Monica M Rao Vinay Kumar VK Choi Min Hee MH Bharathy Narendra N Taneja Reshma R
Scientific reports 20160926
In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutations of sarcomere proteins. This study provides evidence that G9a represses expression of several sarcomere genes and its over-expression disrupts sarcomere integrity of skeletal musc ...[more]