Ontology highlight
ABSTRACT:
SUBMITTER: Dere E
PROVIDER: S-EPMC5036622 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Dere Edward E Wilson Shelby K SK Anderson Linnea M LM Boekelheide Kim K
Toxicological sciences : an official journal of the Society of Toxicology 20160727 2
Traditional testis histopathology endpoints remain the gold standard for evaluating testicular insult and injury in a non-clinical setting, but are invasive and unfeasible for monitoring these effects clinically in humans. Assessing testicular injury in humans relies on semen and serum hormone analyses, both of which are insensitive and poor indicators of effect. Therefore, we hypothesized that sperm messenger RNA (mRNA) transcripts and DNA methylation marks can be used as translatable and sensi ...[more]