Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.
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ABSTRACT:
SUBMITTER: Furusawa C
PROVIDER: S-EPMC5036821 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression.
Furusawa Chikara C Yamaguchi Tomoyuki T
PloS one 20160926 9
The immune response by T cells usually discriminates self and non-self antigens, even though the negative selection of self-reactive T cells is imperfect and a certain fraction of T cells can respond to self-antigens. In this study, we construct a simple mathematical model of T cell populations to analyze how such self/non-self discrimination is possible. The results demonstrate that the control of the immune response by regulatory T cells enables a robust and accurate discrimination of self and ...[more]
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