Analysis of SOX2-Regulated Transcriptome in Glioma Stem Cells.

ABSTRACT:

Introduction

Glioblastoma is the most malignant brain tumor in adults and is associated with poor survival despite multimodal treatments. Glioma stem-like cells (GSCs) are cells functionally defined by their self-renewal potential and the ability to reconstitute the original tumor upon orthotopic implantation. They have been postulated to be the culprit of glioma chemo- and radio-resistance ultimately leading to relapse. Understanding the molecular circuits governing the GSC compartment is essential. SOX2, a critical transcription regulator of embryonic and neural stem cell function, is deregulated in GSCs however; the precise molecular pathways regulated by this gene in GSCs remain poorly understood.

Results

We performed a genome-wide analysis of SOX2-regulated transcripts

SUBMITTER: Acanda de la Rocha AM 

PROVIDER: S-EPMC5036841 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature