Ontology highlight
ABSTRACT:
SUBMITTER: Choi Y
PROVIDER: S-EPMC5036863 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Choi Yoonjoo Y Ndong Christian C Griswold Karl E KE Bailey-Kellogg Chris C
Protein engineering, design & selection : PEDS 20160621 10
Humanization reduces the immunogenicity risk of therapeutic antibodies of non-human origin. Thermostabilization can be critical for clinical development and application of therapeutic antibodies. Here, we show that the computational antibody redesign method Computationally Driven Antibody Humanization (CoDAH) enables these two goals to be accomplished simultaneously and seamlessly. A panel of CoDAH designs for the murine parent of cetuximab, a chimeric anti-EGFR antibody, exhibited both substant ...[more]