Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization.
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ABSTRACT:
SUBMITTER: Angsana J
PROVIDER: S-EPMC5036921 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Efferocytosis as a regulator of macrophage chemokine receptor expression and polarization.
Angsana Julianty J Chen Jiaxuan J Liu Liying L Haller Carolyn A CA Chaikof Elliot L EL
European journal of immunology 20160520 7
Efferocytosis has been suggested to promote macrophage resolution programs that are dependent on motility and emigration, however, few studies have addressed directed migration in resolving macrophages. In this report, we hypothesized that efferocytosis would induce differential chemokine receptor expression. Polarized macrophage populations, including macrophages actively engaged in efferocytosis, were characterized by PCR array and traditional transwell motility assays. We identified specific ...[more]
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