Ontology highlight
ABSTRACT:
SUBMITTER: Garas FN
PROVIDER: S-EPMC5036963 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Garas Farid N FN Shah Rahul S RS Kormann Eszter E Doig Natalie M NM Vinciati Federica F Nakamura Kouichi C KC Dorst Matthijs C MC Smith Yoland Y Magill Peter J PJ Sharott Andrew A
eLife 20160926
Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate st ...[more]