Ontology highlight
ABSTRACT:
SUBMITTER: Talukdar R
PROVIDER: S-EPMC5037034 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Talukdar Rupjyoti R Sareen Archana A Zhu Hongyan H Yuan Zuobiao Z Dixit Ajay A Cheema Hassam H George John J Barlass Usman U Sah Raghuwansh R Garg Sushil K SK Banerjee Sulagna S Garg Pramod P Dudeja Vikas V Dawra Rajinder R Saluja Ashok K AK
Gastroenterology 20160809 4
<h4>Background & aims</h4>Experimental studies in acute pancreatitis (AP) suggest a strong association of acinar cell injury with cathepsin B-dependent intracellular activation of trypsin. However, the molecular events subsequent to trypsin activation and their role, if any, in cell death is not clear. In this study, we have explored intra-acinar events downstream of trypsin activation that lead to acinar cell death.<h4>Methods</h4>Acinar cells prepared from the pancreas of rats or mice (wild-ty ...[more]