Ontology highlight
ABSTRACT:
SUBMITTER: Merhautova J
PROVIDER: S-EPMC5037200 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20160927
Gastrointestinal cancer accounts for the 20 most frequent cancer diseases worldwide and there is a constant urge to bring new therapeutics with new mechanism of action into the clinical practice. Quantity of <i>in vitro</i> and <i>in vivo</i> evidences indicate, that exogenous change in pathologically imbalanced microRNAs (miRNAs) is capable of transforming the cancer cell phenotype. This review analyzed preclinical miRNA-based therapy attempts in animal models of gastric, pancreatic, gallbladde ...[more]