Ontology highlight
ABSTRACT:
SUBMITTER: Rahman N
PROVIDER: S-EPMC5037342 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Rahman Nawreen N Ramos-Espiritu Lavoisier L Milner Teresa A TA Buck Jochen J Levin Lonny R LR
The Journal of general physiology 20161001 4
Lysosomes, the degradative organelles of the endocytic and autophagic pathways, function at an acidic pH. Lysosomes are acidified by the proton-pumping vacuolar ATPase (V-ATPase), but the molecular processes that set the organelle's pH are not completely understood. In particular, pH-sensitive signaling enzymes that can regulate lysosomal acidification in steady-state physiological conditions have yet to be identified. Soluble adenylyl cyclase (sAC) is a widely expressed source of cAMP that serv ...[more]