Ontology highlight
ABSTRACT:
SUBMITTER: Baeyens N
PROVIDER: S-EPMC5037412 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Baeyens Nicolas N Larrivée Bruno B Ola Roxana R Hayward-Piatkowskyi Brielle B Dubrac Alexandre A Huang Billy B Ross Tyler D TD Coon Brian G BG Min Elizabeth E Tsarfati Maya M Tong Haibin H Eichmann Anne A Schwartz Martin A MA
The Journal of cell biology 20160919 7
Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations in Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 and 10. Evidence suggests that a second hit results in clonal expansion of endothelial cells to form lesions with poor ...[more]