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Molecular basis of human cerebral malaria development.

ABSTRACT: Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.

SUBMITTER: Wah ST

PROVIDER: S-EPMC5037602 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Molecular basis of human cerebral malaria development.

Wah Saw Thu ST Hananantachai Hathairad H Kerdpin Usanee U Plabplueng Chotiros C Prachayasittikul Virapong V Nuchnoi Pornlada P

Tropical medicine and health 20160927

Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much ...[more]

PMID: 27708543

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