Ontology highlight
ABSTRACT:
SUBMITTER: Silva RA
PROVIDER: S-EPMC5037663 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Silva Rosemeire A RA Giordano Ricardo J RJ Gutierrez Paulo S PS Rocha Viviane Z VZ Rudnicki Martina M Kee Patrick P Abdalla Dulcinéia S P DS Puech-Leão Pedro P Caramelli Bruno B Arap Wadih W Pasqualini Renata R Meneghetti José C JC Marques Fabio L N FL Khoobchandani Menka M Katti Kattesh V KV Lugão Ademar B AB Kalil Jorge J
International journal of molecular sciences 20160824 9
The purpose of our work was to select phages displaying peptides capable of binding to vascular markers present in human atheroma, and validate their capacity to target the vascular markers in vitro and in low-density lipoprotein receptor knockout (LDLr(-/-)) mouse model of atherosclerosis. By peptide fingerprinting on human atherosclerotic tissues, we selected and isolated four different peptides sequences, which bind to atherosclerotic lesions and share significant similarity to known human pr ...[more]