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Mammalian Metallothionein-2A and Oxidative Stress.

ABSTRACT: Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation. For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. Recent studies have highlighted that oxidative stress could activate mitogen-activated protein kinases (MAPKs), and MT2A, as a mediator of MAPKs, to regulate the pathogenesis of various diseases. However, the molecule mechanism of MT2A remains elusive. A deeper understanding of the functional, biochemical and molecular characteristics of MT2A would be identified, in order to bring new opportunities for oxidative stress therapy.

SUBMITTER: Ling XB

PROVIDER: S-EPMC5037761 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Mammalian Metallothionein-2A and Oxidative Stress.

Ling Xue-Bin XB Wei Hong-Wei HW Wang Jun J Kong Yue-Qiong YQ Wu Yu-You YY Guo Jun-Li JL Li Tian-Fa TF Li Ji-Ke JK

International journal of molecular sciences 20160906 9

Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation. For many years, most studies evaluating the effects of MT2A have focused on reactive oxygen species (ROS), as second messengers that lead to oxidative stress injury of cells and tissues. Recent studies have highlighted that oxidative stress could activate mitogen-activated protein kinases (MAPKs), ...[more]

PMID: 27608012

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