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Development of Novel Immunotherapies for Multiple Myeloma.

ABSTRACT: Multiple myeloma (MM) is a disorder of terminally differentiated plasma cells characterized by clonal expansion in the bone marrow (BM). It is the second-most common hematologic malignancy. Despite significant advances in therapeutic strategies, MM remains a predominantly incurable disease emphasizing the need for the development of new treatment regimens. Immunotherapy is a promising treatment modality to circumvent challenges in the management of MM. Many novel immunotherapy strategies, such as adoptive cell therapy and monoclonal antibodies, are currently under investigation in clinical trials, with some already demonstrating a positive impact on patient survival. In this review, we will summarize the current standards of care and discuss major new approaches in immunotherapy for MM.

SUBMITTER: Al-Hujaily EM

PROVIDER: S-EPMC5037783 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Development of Novel Immunotherapies for Multiple Myeloma.

Al-Hujaily Ensaf M EM Oldham Robyn A A RA Hari Parameswaran P Medin Jeffrey A JA

International journal of molecular sciences 20160908 9

Multiple myeloma (MM) is a disorder of terminally differentiated plasma cells characterized by clonal expansion in the bone marrow (BM). It is the second-most common hematologic malignancy. Despite significant advances in therapeutic strategies, MM remains a predominantly incurable disease emphasizing the need for the development of new treatment regimens. Immunotherapy is a promising treatment modality to circumvent challenges in the management of MM. Many novel immunotherapy strategies, such a ...[more]

PMID: 27618026

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Novel Immunotherapies for Multiple Myeloma.

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Immunotherapies targeting CD38 in Multiple Myeloma.

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Project description:The therapeutic landscape of multiple myeloma (MM) has dramatically changed in the last 15 years with the advent of immunomodulatory drugs and proteasome inhibitors. However, majority of MM patients relapse, and new therapies are needed. Various agents with diverse mechanisms of action and distinct targets, including cellular therapies, monoclonal antibodies, and small molecules, are currently under investigation. In this review, we report novel drugs recently approved or under advanced investigation that will likely be incorporated in the future as new standard for MM treatment, focusing on their mechanisms of action, cellular targets, and stage of development.

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Multiple myeloma

Project description:Multiple myeloma

| PRJNA515992 | ENA

A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.

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