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Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators.

ABSTRACT: This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field.

SUBMITTER: Perez-Regidor L

PROVIDER: S-EPMC5037785 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators.

Pérez-Regidor Lucía L Zarioh Malik M Ortega Laura L Martín-Santamaría Sonsoles S

International journal of molecular sciences 20160909 9

This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virt ...[more]

PMID: 27618029

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