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Progress on new vaccine strategies against chronic viral infections.

ABSTRACT: Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for the vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses--quantitative and qualitative--than does the natural virus. Here we examine the immunologic and virologic basis for vaccines against three such viruses, HIV, hepatitis C virus, and human papillomavirus, and review progress in clinical trials to date. We also explore novel strategies for increasing the immunogenicity and efficacy of vaccines.

SUBMITTER: Berzofsky JA

PROVIDER: S-EPMC503779 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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Progress on new vaccine strategies against chronic viral infections.

Berzofsky Jay A JA Ahlers Jeffrey D JD Janik John J Morris John J Oh SangKon S Terabe Masaki M Belyakov Igor M IM

The Journal of clinical investigation 20040801 4

Among the most cost-effective strategies for preventing viral infections, vaccines have proven effective primarily against viruses causing acute, self-limited infections. For these it has been sufficient for the vaccine to mimic the natural virus. However, viruses causing chronic infection do not elicit an immune response sufficient to clear the infection and, as a result, vaccines for these viruses must elicit more effective responses--quantitative and qualitative--than does the natural virus. ...[more]

PMID: 15314679

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