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Protein Kinases and Parkinson's Disease.


ABSTRACT: Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson's disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson's disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson's disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules.

SUBMITTER: Mehdi SJ 

PROVIDER: S-EPMC5037850 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Protein Kinases and Parkinson's Disease.

Mehdi Syed Jafar SJ   Rosas-Hernandez Hector H   Cuevas Elvis E   Lantz Susan M SM   Barger Steven W SW   Sarkar Sumit S   Paule Merle G MG   Ali Syed F SF   Imam Syed Z SZ  

International journal of molecular sciences 20160920 9


Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson's disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing bec  ...[more]

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