Ontology highlight
ABSTRACT:
SUBMITTER: Laskaris P
PROVIDER: S-EPMC5038287 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Laskaris Paris P Atrouni Ahmad A Calera José Antonio JA d'Enfert Christophe C Munier-Lehmann Hélène H Cavaillon Jean-Marc JM Latgé Jean-Paul JP Ibrahim-Granet Oumaïma O
Antimicrobial agents and chemotherapy 20160923 10
Aspergillus fumigatus can infect immunocompromised patients, leading to high mortality rates due to the lack of reliable treatment options. This pathogen requires uptake of zinc from host tissues in order to successfully grow and cause virulence. Reducing the availability of that micronutrient could help treat A. fumigatus infections. In this study, we examined the in vitro effects of seven chelators using a bioluminescent strain of A. fumigatus 1,10-Phenanthroline and N,N,N',N'-tetrakis(2-pyrid ...[more]