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Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.


ABSTRACT: Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.

SUBMITTER: Venkateswaran S 

PROVIDER: S-EPMC5038341 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.

Venkateswaran Seshasailam S   Henrique Dos Santos Orlando David OD   Scholefield Emma E   Lilienkampf Annamaria A   Gwynne Peter J PJ   Swann David G DG   Dhaliwal Kevin K   Gallagher Maurice P MP   Bradley Mark M  

Journal of materials chemistry. B 20160718 32


Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bac  ...[more]

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